Pharma Science Monitor an International Journal of Pharmaceutical Sciences a Review: Pyrazolopyrimidine Moiety

Department of Pharmaceutical technology, Meerut Institute of Engineering and Technology, Meerut. ABSTRACT Pyrazole and pyrimidine derivatives attracted organic chemists due to their various biological and chemotherapeutic significance. Pyrazolopyrimidines and related fused heterocycles are of important as probable bioactive molecules. The heterocyclic fusion of pyrimidine ring and pyrazole ring resulted in formation of pyrazolopyrimidines, the structural analogues of biogenic purine class, definitely, has high impact in the field of pharmaceutical and biotechnological sciences with vast spectrum of biological activities. Several pharmacological actvities like mitotic, CNS stimulant, analgesic, antiinflammatory, antiasthmatic, antibacterial and anticancer activity have been attributed. Numerous pyrazolopyrimidine derivatives have been found to possess considerable biolgical activities, which stimulated the research activity ion this field. Pyrazolopyrimidine derivative show inhibitory activity towards both tubulin polymerization and cyclin dependent kinase.